The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability

Notch and Angiopoietin-1 (Ang1)/Tie2 pathways are crucial for vascular maturation and stability. Here we identify the transcription factor ERG as a key regulator of endothelial Notch signalling. We show that ERG controls the balance between Notch ligands by driving Delta-like ligand 4 (Dll4) while r...

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Publicado en:Nat Commun
Main Authors: Shah, A. V., Birdsey, G. M., Peghaire, C., Pitulescu, M. E., Dufton, N. P., Yang, Y., Weinberg, I., Osuna Almagro, L., Payne, L., Mason, J. C., Gerhardt, H., Adams, R. H., Randi, A. M.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5508205/
https://ncbi.nlm.nih.gov/pubmed/28695891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms16002
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