Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis

The role of the endothelium in protecting from chronic liver disease and TGFβ-mediated fibrosis remains unclear. Here we describe how the endothelial transcription factor ETS-related gene (ERG) promotes liver homoeostasis by controlling canonical TGFβ-SMAD signalling, driving the SMAD1 pathway while...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Dufton, Neil P., Peghaire, Claire R., Osuna-Almagro, Lourdes, Raimondi, Claudio, Kalna, Viktoria, Chauhan, Abhishek, Webb, Gwilym, Yang, Youwen, Birdsey, Graeme M., Lalor, Patricia, Mason, Justin C., Adams, David H., Randi, Anna M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5638819/
https://ncbi.nlm.nih.gov/pubmed/29026072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01169-0
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