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The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability
Notch and Angiopoietin-1 (Ang1)/Tie2 pathways are crucial for vascular maturation and stability. Here we identify the transcription factor ERG as a key regulator of endothelial Notch signalling. We show that ERG controls the balance between Notch ligands by driving Delta-like ligand 4 (Dll4) while r...
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| Gepubliceerd in: | Nat Commun |
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| Hoofdauteurs: | , , , , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5508205/ https://ncbi.nlm.nih.gov/pubmed/28695891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms16002 |
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