Differential signaling networks of Bcr–Abl p210 and p190 kinases in leukemia cells defined by functional proteomics

The two major isoforms of the oncogenic Bcr–Abl tyrosine kinase, p210 and p190, are expressed upon the Philadelphia chromosome translocation. p210 is the hallmark of chronic myelogenous leukemia, whereas p190 occurs in the majority of B-cell acute lymphoblastic leukemia. Differences in protein inter...

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Bibliographic Details
Published in:Leukemia
Main Authors: Reckel, S, Hamelin, R, Georgeon, S, Armand, F, Jolliet, Q, Chiappe, D, Moniatte, M, Hantschel, O
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5508078/
https://ncbi.nlm.nih.gov/pubmed/28111465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.36
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