Differential signaling networks of Bcr–Abl p210 and p190 kinases in leukemia cells defined by functional proteomics

The two major isoforms of the oncogenic Bcr–Abl tyrosine kinase, p210 and p190, are expressed upon the Philadelphia chromosome translocation. p210 is the hallmark of chronic myelogenous leukemia, whereas p190 occurs in the majority of B-cell acute lymphoblastic leukemia. Differences in protein inter...

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Publicat a:Leukemia
Autors principals: Reckel, S, Hamelin, R, Georgeon, S, Armand, F, Jolliet, Q, Chiappe, D, Moniatte, M, Hantschel, O
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5508078/
https://ncbi.nlm.nih.gov/pubmed/28111465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.36
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