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DNA methylation age-acceleration is associated with disease duration and age at onset in C9orf72 patients

The repeat expansion in C9orf72 is the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia. C9orf72 patients present with a wide range in disease duration and age of onset. The strongest risk factor for both syndromes is aging, which was linked to DNA methylation (DNAm) ag...

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Detaylı Bibliyografya
Yayımlandı:Acta Neuropathol
Asıl Yazarlar: Zhang, Ming, Tartaglia, Maria Carmela, Moreno, Danielle, Sato, Christine, McKeever, Paul, Weichert, Anna, Keith, Julia, Robertson, Janice, Zinman, Lorne, Rogaeva, Ekaterina
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer Berlin Heidelberg 2017
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5508035/
https://ncbi.nlm.nih.gov/pubmed/28439722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-017-1713-y
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