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DNA methylation age-acceleration is associated with disease duration and age at onset in C9orf72 patients
The repeat expansion in C9orf72 is the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia. C9orf72 patients present with a wide range in disease duration and age of onset. The strongest risk factor for both syndromes is aging, which was linked to DNA methylation (DNAm) ag...
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| Published in: | Acta Neuropathol |
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| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Springer Berlin Heidelberg
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5508035/ https://ncbi.nlm.nih.gov/pubmed/28439722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-017-1713-y |
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