DNA methylation age-acceleration is associated with disease duration and age at onset in C9orf72 patients

The repeat expansion in C9orf72 is the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia. C9orf72 patients present with a wide range in disease duration and age of onset. The strongest risk factor for both syndromes is aging, which was linked to DNA methylation (DNAm) ag...

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Vydáno v:Acta Neuropathol
Hlavní autoři: Zhang, Ming, Tartaglia, Maria Carmela, Moreno, Danielle, Sato, Christine, McKeever, Paul, Weichert, Anna, Keith, Julia, Robertson, Janice, Zinman, Lorne, Rogaeva, Ekaterina
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2017
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Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5508035/
https://ncbi.nlm.nih.gov/pubmed/28439722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-017-1713-y
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