Hypermethylation of the CpG Island Near the G(4)C(2) Repeat in ALS with a C9orf72 Expansion

The G(4)C(2) repeat expansion in C9orf72 is the most common known cause of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). We tested the hypothesis that the repeat expansion causes aberrant CpG methylation near the G(4)C(2) repeat, which could be responsible for the...

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Détails bibliographiques
Auteurs principaux: Xi, Zhengrui, Zinman, Lorne, Moreno, Danielle, Schymick, Jennifer, Liang, Yan, Sato, Christine, Zheng, Yonglan, Ghani, Mahdi, Dib, Samar, Keith, Julia, Robertson, Janice, Rogaeva, Ekaterina
Format: Artigo
Langue:Inglês
Publié: Elsevier 2013
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675239/
https://ncbi.nlm.nih.gov/pubmed/23731538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2013.04.017
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