Differential role of pannexin-1/ATP/P2X(7) axis in IL-1β release by human monocytes

IL-1β release is integral to the innate immune system. The release of mature IL-1β depends on 2 regulated events: the de novo induction of pro-IL-1β, generally via NF-κB-dependent transduction pathways; and the assembly and activation of the NLRP3 inflammasome. This latter step is reliant on active...

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Vydáno v:FASEB J
Hlavní autoři: Parzych, Katarzyna, Zetterqvist, Anna V., Wright, William R., Kirkby, Nicholas S., Mitchell, Jane A., Paul-Clark, Mark J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5507675/
https://ncbi.nlm.nih.gov/pubmed/28246166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201600256
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