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Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells
A 1,2-dioxolane (FINO(2)) was identified as a lead compound from a screen of organic peroxides. FINO(2) does not induce apoptosis, but instead initiates ferroptosis, an iron-dependent, oxidative cell death pathway. Few compounds are known to induce primarily ferroptosis. In contrast to the perceived...
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| Publicado no: | ACS Chem Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5507670/ https://ncbi.nlm.nih.gov/pubmed/26797166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00900 |
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