Structural basis of TPR mediated oligomerization and activation of oncogenic fusion kinases

The nuclear pore complex subunit TPR is found in at least five different oncogenic fusion kinases, including TPR-MET, yet how TPR fusions promote activation of kinases and their oncogenic activities remains poorly understood. Here we report the crystal structure of TPR(2-142), the MET fusion partner...

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Publicado no:Structure
Main Authors: Pal, Kuntal, Bandyopadhyay, Abhishek, Zhou, X. Edward, Xu, Qingping, Marciano, David P., Brunzelle, Joseph S., Yerrum, Smitha, Griffin, Patrick R., Woude, George Vande, Melcher, Karsten, Xu, H. Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5507626/
https://ncbi.nlm.nih.gov/pubmed/28528776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.04.015
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