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Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1
R loop, a transcription intermediate containing RNA:DNA hybrids and displaced single-stranded DNA (ssDNA), has emerged as a major source of genomic instability. RNaseH1, which cleaves the RNA in RNA:DNA hybrids, plays an important role in R loop suppression. Here, we show that replication protein A...
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| Veröffentlicht in: | Mol Cell |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5507214/ https://ncbi.nlm.nih.gov/pubmed/28257700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.01.029 |
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