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ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop
R loops arising during transcription induce genomic instability, but how cells respond to the R loop-associated genomic stress is still poorly understood. Here, we show that cells harboring high levels of R loops rely on the ATR kinase for survival. In response to aberrant R loop accumulation, the A...
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| Publicado en: | Mol Cell |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7007873/ https://ncbi.nlm.nih.gov/pubmed/31708417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.10.010 |
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