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Elucidating drug targets and mechanisms of action by genetic screens in mammalian cells
Phenotypic screening is a powerful approach to discover small molecules with desired effects on biological systems, which can then be developed into therapeutic drugs. The identification of the target and mechanism of action of compounds discovered in phenotypic screens remains a major challenge. Th...
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| Udgivet i: | Chem Commun (Camb) |
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| Hovedforfatter: | |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5507204/ https://ncbi.nlm.nih.gov/pubmed/28487920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7cc02349a |
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