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Functional genomics platform for pooled screening and mammalian genetic interaction maps

Systematic genetic interaction maps in microorganisms are powerful tools for identifying functional relationships between genes and defining the function of uncharacterized genes. We have recently implemented this strategy in mammalian cells as a two-stage approach. First, genes of interest are robu...

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Main Authors: Kampmann, Martin, Bassik, Michael C., Weissman, Jonathan S.
格式: Artigo
語言:Inglês
出版: 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144868/
https://ncbi.nlm.nih.gov/pubmed/24992097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nprot.2014.103
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