Exosomal microRNA transfer into macrophages mediates cellular postconditioning de Couto: Exosomal RNA transfer modulates macrophages

BACKGROUND: Cardiosphere-derived cells (CDCs) confer cardioprotection in acute myocardial infarction (MI) via distinctive macrophage (Mϕ) polarization. Here we demonstrate that CDC-secreted exosomes (CDC(exo)) recapitulate the cardioprotective effects of CDC therapy known as cellular postconditionin...

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Dettagli Bibliografici
Pubblicato in:Circulation
Autori principali: de Couto, Geoffrey, Gallet, Romain, Cambier, Linda, Jaghatspanyan, Ervin, Makkar, Nupur, Dawkins, James Frederick, Berman, Benjamin P., Marbán, Eduardo
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505791/
https://ncbi.nlm.nih.gov/pubmed/28411247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.116.024590
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