Exosomes secreted by cardiosphere-derived cells reduce scarring, attenuate adverse remodelling, and improve function in acute and chronic porcine myocardial infarction

AIMS: Naturally secreted nanovesicles known as exosomes are required for the regenerative effects of cardiosphere-derived cells (CDCs), and exosomes mimic the benefits of CDCs in rodents. Nevertheless, exosomes have not been studied in a translationally realistic large-animal model. We sought to opt...

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Detalles Bibliográficos
Publicado en:Eur Heart J
Main Authors: Gallet, Romain, Dawkins, James, Valle, Jackelyn, Simsolo, Eli, de Couto, Geoffrey, Middleton, Ryan, Tseliou, Eleni, Luthringer, Daniel, Kreke, Michelle, Smith, Rachel R., Marbán, Linda, Ghaleh, Bijan, Marbán, Eduardo
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2017
Assuntos:
Basic Science
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837390/
https://ncbi.nlm.nih.gov/pubmed/28158410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehw240
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