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Biosynthesis and Regulation of Sulfomenaquinone, a Metabolite Associated with Virulence in Mycobacterium tuberculosis

Sulfomenaquinone (SMK) is a recently identified metabolite that is unique to the Mycobacterium tuberculosis (M. tuberculosis) complex and is shown to modulate its virulence. Here, we report the identification of the SMK biosynthetic operon that, in addition to a previously identified sulfotransferas...

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Veröffentlicht in:ACS Infect Dis
Hauptverfasser: Sogi, Kimberly M., Holsclaw, Cynthia M., Fragiadakis, Gabriela K., Nomura, Daniel K., Leary, Julie A., Bertozzi, Carolyn R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505729/
https://ncbi.nlm.nih.gov/pubmed/27933784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.6b00106
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