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Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers

The amyloid β peptide (Aβ) is a key player in the etiology of Alzheimer disease (AD), yet a systematic investigation of its molecular interactions has not been reported. Here we identified by quantitative mass spectrometry proteins in human brain extract that bind to oligomeric Aβ1-42 (oAβ1-42) and/...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Wang, Hansen, Muiznieks, Lisa D, Ghosh, Punam, Williams, Declan, Solarski, Michael, Fang, Andrew, Ruiz-Riquelme, Alejandro, Pomès, Régis, Watts, Joel C, Chakrabartty, Avi, Wille, Holger, Sharpe, Simon, Schmitt-Ulms, Gerold
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505701/
https://ncbi.nlm.nih.gov/pubmed/28650319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28401
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