Simplified AIP-II Peptidomimetics Are Potent Inhibitors of Staphylococcus aureus AgrC Quorum Sensing Receptors

The bacterial pathogen Staphylococcus aureus controls many aspects of virulence by using the accessory gene regulator (agr) quorum sensing (QS) system. The agr system is activated by a macrocyclic peptide signal known as an autoinducing peptide (AIP). We sought to develop structurally simplified mim...

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Bibliographic Details
Published in:Chembiochem
Main Authors: Vasquez, Joseph K., Tal-Gan, Yftah, Cornilescu, Gabriel, Tyler, Kimberly A., Blackwell, Helen E.
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505641/
https://ncbi.nlm.nih.gov/pubmed/28006082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201600516
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