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Simplified AIP-II Peptidomimetics Are Potent Inhibitors of Staphylococcus aureus AgrC Quorum Sensing Receptors

The bacterial pathogen Staphylococcus aureus controls many aspects of virulence by using the accessory gene regulator (agr) quorum sensing (QS) system. The agr system is activated by a macrocyclic peptide signal known as an autoinducing peptide (AIP). We sought to develop structurally simplified mim...

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Publicado en:Chembiochem
Main Authors: Vasquez, Joseph K., Tal-Gan, Yftah, Cornilescu, Gabriel, Tyler, Kimberly A., Blackwell, Helen E.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505641/
https://ncbi.nlm.nih.gov/pubmed/28006082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201600516
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