Comparison of a mouse and a novel human scFv-SNAP-auristatin F drug conjugate with potent activity against EGFR-overexpressing human solid tumor cells

Antibody–drug conjugates (ADCs) can deliver toxins to specific targets such as tumor cells. They have shown promise in preclinical/clinical development but feature stoichiometrically undefined chemical linkages, and those based on full-size antibodies achieve only limited tumor penetration. SNAP-tag...

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Bibliographic Details
Published in:Onco Targets Ther
Main Authors: Woitok, Mira, Klose, Diana, Di Fiore, Stefano, Richter, Wolfgang, Stein, Christoph, Gresch, Gerrit, Grieger, Elena, Barth, Stefan, Fischer, Rainer, Kolberg, Katharina, Niesen, Judith
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2017
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505605/
https://ncbi.nlm.nih.gov/pubmed/28740407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S140492
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