Targetable T-type calcium channels drive glioblastoma

Glioblastoma stem-like cells (GSC) promote tumor initiation, progression and therapeutic resistance. Here we show how GSC can be targeted by the FDA approved drug mibefradil which inhibits the T-type calcium channel Cav3.2. This calcium channel was highly expressed in human GBM specimens and enriche...

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Dades bibliogràfiques
Publicat a:Cancer Res
Autors principals: Zhang, Ying, Cruickshanks, Nichola, Yuan, Fang, Wang, Baomin, Pahuski, Mary, Wulfkuhle, Julia, Gallagher, Isela, Koeppel, Alexander F., Hatef, Sarah, Papanicolas, Christopher, Lee, Jeongwu, Bar, Eli, Schiff, David, Turner, Stephen D., Petricoin, Emanuel, Gray, Lloyd, Abounader, Roger
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505315/
https://ncbi.nlm.nih.gov/pubmed/28512247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2347
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