Discovery and therapeutic exploitation of mechanisms of resistance to MET inhibitors in glioblastoma

PURPOSE: Glioblastoma (GBM) is the most common and most lethal primary malignant brain tumor. The receptor tyrosine kinase MET is frequently upregulated or over activated in GBM. Although clinically applicable MET inhibitors have been developed, resistance to single modality anti-MET drugs frequentl...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Cruickshanks, Nichola, Zhang, Ying, Hine, Sarah, Gibert, Myron, Yuan, Fang, Oxford, Madison, Grello, Cassandra, Pahuski, Mary, Dube, Collin, Guessous, Fadila, Wang, Baomin, Deveau, Ciana, Saoud, Karim, Gallagher, Isela, Wulfkuhle, Julia, Schiff, David, Phan, See, Petricoin, Emanuel, Abounader, Roger
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6335175/
https://ncbi.nlm.nih.gov/pubmed/30201763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0926
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