Discovery and therapeutic exploitation of mechanisms of resistance to MET inhibitors in glioblastoma

PURPOSE: Glioblastoma (GBM) is the most common and most lethal primary malignant brain tumor. The receptor tyrosine kinase MET is frequently upregulated or over activated in GBM. Although clinically applicable MET inhibitors have been developed, resistance to single modality anti-MET drugs frequentl...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Cruickshanks, Nichola, Zhang, Ying, Hine, Sarah, Gibert, Myron, Yuan, Fang, Oxford, Madison, Grello, Cassandra, Pahuski, Mary, Dube, Collin, Guessous, Fadila, Wang, Baomin, Deveau, Ciana, Saoud, Karim, Gallagher, Isela, Wulfkuhle, Julia, Schiff, David, Phan, See, Petricoin, Emanuel, Abounader, Roger
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6335175/
https://ncbi.nlm.nih.gov/pubmed/30201763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0926
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