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Delivery of Chemotherapeutics Across the Blood–Brain Barrier: Challenges and Advances
The blood–brain barrier (BBB) limits drug delivery to brain tumors. We utilize intraarterial infusion of hyperosmotic mannitol to reversibly open the BBB by shrinking endothelial cells and opening tight junctions between the cells. This approach transiently increases the delivery of chemotherapy, an...
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| Pubblicato in: | Adv Pharmacol |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5505259/ https://ncbi.nlm.nih.gov/pubmed/25307218 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.apha.2014.06.002 |
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