Delivery of Chemotherapeutics Across the Blood–Brain Barrier: Challenges and Advances

The blood–brain barrier (BBB) limits drug delivery to brain tumors. We utilize intraarterial infusion of hyperosmotic mannitol to reversibly open the BBB by shrinking endothelial cells and opening tight junctions between the cells. This approach transiently increases the delivery of chemotherapy, an...

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Udgivet i:Adv Pharmacol
Main Authors: Doolittle, Nancy D., Muldoon, Leslie L., Culp, Aliana Y., Neuwelt, Edward A.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505259/
https://ncbi.nlm.nih.gov/pubmed/25307218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.apha.2014.06.002
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