Surface Expression of TGF-β Docking Receptor GARP Promotes Oncogenesis and Immune Tolerance in Breast Cancer

GARP encoded by the Lrrc32 gene is the cell surface docking receptor for latent TGF-β which is expressed naturally by platelets and regulatory T cells. Although Lrrc32 is amplified frequently in breast cancer, the expression and relevant functions of GARP in cancer have not been explored. Here we re...

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Publicat a:Cancer Res
Autors principals: Metelli, Alessandra, Wu, Bill X, Fugle, Caroline W, Rachidi, Saleh, Sun, Shaoli, Zhang, Yongliang, Wu, Jennifer, Tomlinson, Stephen, Howe, Philip, Yang, Yi, Garrett-Mayer, Elizabeth, Liu, Bei, Li, Zihai
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5504525/
https://ncbi.nlm.nih.gov/pubmed/27913437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1456
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