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2′-O-Methyl-5-hydroxymethylcytidine: A Second Oxidative Derivative of 5-Methylcytidine in RNA

[Image: see text] 5-Hydroxymethylcytidine (hm(5)C) was recently identified as a direct metabolite of m(5)C in RNA. We investigated the stability of hm(5)C in human cells using bio-isotopologues and LC-MS/HRMS. This has led to the discovery of a second oxidative metabolite of m(5)C in RNA, namely 2′-...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Am Chem Soc
मुख्य लेखकों: Huber, Sabrina M., van Delft, Pieter, Tanpure, Arun, Miska, Eric A., Balasubramanian, Shankar
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Chemical Society 2017
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5504488/
https://ncbi.nlm.nih.gov/pubmed/28107630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b12180
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