Calcineurin inhibitor cyclosporine A activates renal Na-K-Cl cotransporters via local and systemic mechanisms

Calcineurin dephosphorylates nuclear factor of activated T cells transcription factors, thereby facilitating T cell-mediated immune responses. Calcineurin inhibitors are instrumental for immunosuppression after organ transplantation but may cause side effects, including hypertension and electrolyte...

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Pubblicato in:Am J Physiol Renal Physiol
Autori principali: Blankenstein, K. I., Borschewski, A., Labes, R., Paliege, A., Boldt, C., McCormick, J. A., Ellison, D. H., Bader, M., Bachmann, S., Mutig, K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5504423/
https://ncbi.nlm.nih.gov/pubmed/28003191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00575.2016
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