MicroRNA cluster miR-17-92 regulates multiple functionally related voltage-gated potassium channels in chronic neuropathic pain

miR-17-92 is a microRNA cluster with six distinct members. Here, we show that the miR-17-92 cluster and its individual members modulate chronic neuropathic pain. All cluster members are persistently upregulated in primary sensory neurons after nerve injury. Overexpression of miR-18a, miR-19a, miR-19...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Sakai, Atsushi, Saitow, Fumihito, Maruyama, Motoyo, Miyake, Noriko, Miyake, Koichi, Shimada, Takashi, Okada, Takashi, Suzuki, Hidenori
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5504285/
https://ncbi.nlm.nih.gov/pubmed/28677679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms16079
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