miR‐15b mediates oxaliplatin‐induced chronic neuropathic pain through BACE1 down‐regulation

BACKGROUND AND PURPOSE: Although oxaliplatin is an effective anti‐cancer platinum compound, it can cause painful chronic neuropathy, and its molecular mechanisms are poorly understood. MicroRNAs (miRNAs) are small non‐coding RNAs that negatively regulate gene expression in a sequence‐specific manner...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Ito, Naomi, Sakai, Atsushi, Miyake, Noriko, Maruyama, Motoyo, Iwasaki, Hirotoshi, Miyake, Koichi, Okada, Takashi, Sakamoto, Atsuhiro, Suzuki, Hidenori
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5301044/
https://ncbi.nlm.nih.gov/pubmed/28012171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13698
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