miR‐15b mediates oxaliplatin‐induced chronic neuropathic pain through BACE1 down‐regulation

BACKGROUND AND PURPOSE: Although oxaliplatin is an effective anti‐cancer platinum compound, it can cause painful chronic neuropathy, and its molecular mechanisms are poorly understood. MicroRNAs (miRNAs) are small non‐coding RNAs that negatively regulate gene expression in a sequence‐specific manner...

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Bibliographische Detailangaben
Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Ito, Naomi, Sakai, Atsushi, Miyake, Noriko, Maruyama, Motoyo, Iwasaki, Hirotoshi, Miyake, Koichi, Okada, Takashi, Sakamoto, Atsuhiro, Suzuki, Hidenori
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5301044/
https://ncbi.nlm.nih.gov/pubmed/28012171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13698
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