Amino Acid Substitution K470R in the Nucleoprotein Increases the Virulence of H5N1 Influenza A Virus in Mammals

H5N1 is a highly pathogenic influenza A virus (IAV) and poses a major threat to the public health. The nucleoprotein (NP) has a multiple functions during the viral life cycle, however, the precise role of NP mutants in viral replication and pathogenicity is not completely understood. Here, we attemp...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Chen, Lin, Wang, Chengmin, Luo, Jing, Li, Meng, Liu, Huimin, Zhao, Na, Huang, Jingjing, Zhu, Xili, Ma, Guoyao, Yuan, Guohui, He, Hongxuan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5504190/
https://ncbi.nlm.nih.gov/pubmed/28744280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2017.01308
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