Amino Acid Substitutions HA A150V, PA A343T, and PB2 E627K Increase the Virulence of H5N6 Influenza Virus in Mice

H5N6 avian influenza viruses (AIVs) can cause severe pneumonia and death in humans. However, the molecular determinants of H5N6 influenza virus mammalian adaption are still unclear. Three amino acid substitutions (HA A150V, PA A343T, PB2 E627K) are observed in H5N6 virus A/duck/Zhejiang/6D2/2013 (6D...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Peng, Xiuming, Liu, Fumin, Wu, Haibo, Peng, Xiaorong, Xu, Yufan, Wang, Liyan, Chen, Bin, Sun, Tao, Yang, Fan, Ji, Shujing, Wu, Nanping
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5859062/
https://ncbi.nlm.nih.gov/pubmed/29593694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2018.00453
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