Amino Acid Substitutions HA A150V, PA A343T, and PB2 E627K Increase the Virulence of H5N6 Influenza Virus in Mice

H5N6 avian influenza viruses (AIVs) can cause severe pneumonia and death in humans. However, the molecular determinants of H5N6 influenza virus mammalian adaption are still unclear. Three amino acid substitutions (HA A150V, PA A343T, PB2 E627K) are observed in H5N6 virus A/duck/Zhejiang/6D2/2013 (6D...

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Bibliografiske detaljer
Udgivet i:Front Microbiol
Main Authors: Peng, Xiuming, Liu, Fumin, Wu, Haibo, Peng, Xiaorong, Xu, Yufan, Wang, Liyan, Chen, Bin, Sun, Tao, Yang, Fan, Ji, Shujing, Wu, Nanping
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5859062/
https://ncbi.nlm.nih.gov/pubmed/29593694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2018.00453
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