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Emergence of Avian Influenza Viruses with Enhanced Transcription Activity by a Single Amino Acid Substitution in the Nucleoprotein during Replication in Chicken Brains

To explore the genetic basis of the pathogenesis and adaptation of avian influenza viruses (AIVs) to chickens, the A/duck/Yokohama/aq10/2003 (H5N1) (DkYK10) virus was passaged five times in the brains of chickens. The brain-passaged DkYK10-B5 caused quick death of chickens through rapid and efficien...

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Библиографические подробности
Главные авторы: Tada, Tatsuya, Suzuki, Koutaro, Sakurai, Yu, Kubo, Masanori, Okada, Hironao, Itoh, Toshihiro, Tsukamoto, Kenji
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196427/
https://ncbi.nlm.nih.gov/pubmed/21795332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00605-11
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