Targeting of 12/15-Lipoxygenase in retinal endothelial cells, but not in monocytes/macrophages, attenuates high glucose-induced retinal leukostasis

AIMS: Our previous studies have established a role for 12/15-lipoxygenase (LO) in mediating the inflammatory response in diabetic retinopathy (DR). However, the extent at which the local or systemic induction of 12/15-LO activity involved is unclear. Thus, the current study aimed to characterize the...

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Vydáno v:Biochim Biophys Acta
Hlavní autoři: Ibrahim, Ahmed S, Saleh, Heba, El-Shafey, Mohamed, Hussein, Khaled A, El-Masry, Khaled, Baban, Babak, Sheibani, Nader, Wang, Mong-Heng, Tawfik, Amany, Al-Shabrawey, Mohamed
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5504079/
https://ncbi.nlm.nih.gov/pubmed/28351645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2017.03.010
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