Pigment Epithelium-Derived Factor Inhibits Retinal Microvascular Dysfunction Induced By 12/15-Lipoxygenase-Derived Eicosanoids

We recently demonstrated that 12/15-lipoxygenase (LOX) derived metabolites, hydroxyeicosatetraenoic acids (HETEs), contribute to diabetic retinopathy (DR) via NADPH oxidase (NOX) and disruption of the balance in retinal levels of the vascular endothelial growth factor (VEGF) and Pigment Epithelium-D...

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Pubblicato in:Biochim Biophys Acta
Autori principali: Ibrahim, Ahmed S., Tawfik, Amany M., Hussein, Khaled A, Elshafey, Sally, Markand, Shanu, Rizk, Nasser, Duh, Elia J., Smith, Sylvia B., Al-Shabrawey, Mohamed
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312733/
https://ncbi.nlm.nih.gov/pubmed/25562624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2014.12.017
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