Pigment Epithelium-Derived Factor Inhibits Retinal Microvascular Dysfunction Induced By 12/15-Lipoxygenase-Derived Eicosanoids

We recently demonstrated that 12/15-lipoxygenase (LOX) derived metabolites, hydroxyeicosatetraenoic acids (HETEs), contribute to diabetic retinopathy (DR) via NADPH oxidase (NOX) and disruption of the balance in retinal levels of the vascular endothelial growth factor (VEGF) and Pigment Epithelium-D...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Ibrahim, Ahmed S., Tawfik, Amany M., Hussein, Khaled A, Elshafey, Sally, Markand, Shanu, Rizk, Nasser, Duh, Elia J., Smith, Sylvia B., Al-Shabrawey, Mohamed
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312733/
https://ncbi.nlm.nih.gov/pubmed/25562624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2014.12.017
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