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Analysis of positive and negative allosteric modulation in metabotropic glutamate receptors 4 and 5 with a dual ligand

As class C GPCRs and regulators of synaptic activity, human metabotropic glutamate receptors (mGluRs) 4 and 5 are prime targets for allosteric modulation, with mGlu5 inhibition or mGlu4 stimulation potentially treating conditions like chronic pain and Parkinson’s disease. As an allosteric modulator...

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Foilsithe in:Sci Rep
Main Authors: Dalton, James A. R., Pin, Jean-Philippe, Giraldo, Jesús
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5504000/
https://ncbi.nlm.nih.gov/pubmed/28694498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05095-5
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