Clickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 5 Based on Select Acetylenic Negative Allosteric Modulators

G protein-coupled receptors (GPCRs) represent the largest class of current drug targets. In particular, small-molecule allosteric modulators offer substantial potential for selectively “tuning” GPCR activity. However, there remains a critical need for experimental strategies that unambiguously deter...

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Bibliografiska uppgifter
I publikationen:ACS Chem Biol
Huvudupphovsmän: Gregory, Karen J., Velagaleti, Ranganadh, Thal, David M., Brady, Ryan M., Christopoulos, Arthur, Conn, P. Jeffrey, Lapinsky, David J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4981245/
https://ncbi.nlm.nih.gov/pubmed/27115427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00026
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