Calcium Triggers Reversal of Calmodulin on Nested Anti-Parallel Sites in the IQ Motif of the Neuronal Voltage-Dependent Sodium Channel Na(V)1.2

Several members of the voltage-gated sodium channel family are regulated by calmodulin (CaM) and ionic calcium. The neuronal voltage-gated sodium channel Na(V)1.2 contains binding sites for both apo (calcium-depleted) and calcium-saturated CaM. We have determined equilibrium dissociation constants f...

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Publicat a:Biophys Chem
Autors principals: Hovey, Liam, Fowler, C. Andrew, Mahling, Ryan, Lin, Zesen, Miller, Mark Stephen, Marx, Dagan C., Yoder, Jesse B., Kim, Elaine H., Tefft, Kristin M., Waite, Brett C., Feldkamp, Michael D., Yu, Liping, Shea, Madeline A.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503752/
https://ncbi.nlm.nih.gov/pubmed/28343066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2017.02.006
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