Loss of tumour-specific ATM protein expression is an independent prognostic factor in early resected NSCLC

Ataxia-telangiectasia mutated (ATM) is critical in maintaining genomic integrity. In response to DNA double-strand breaks, ATM phosphorylates downstream proteins involved in cell-cycle checkpoint arrest, DNA repair, and apoptosis. Here we investigate the frequency, and influence of ATM deficiency on...

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Udgivet i:Oncotarget
Main Authors: Petersen, Lars F., Klimowicz, Alexander C., Otsuka, Shannon, Elegbede, Anifat A., Petrillo, Stephanie K., Williamson, Tyler, Williamson, Chris T., Konno, Mie, Lees-Miller, Susan P., Hao, Desiree, Morris, Don, Magliocco, Anthony M., Bebb, D. Gwyn
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503535/
https://ncbi.nlm.nih.gov/pubmed/28418844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16215
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