Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines

Small-molecule inhibitors of poly (ADP-ribose) polymerase (PARP) have shown considerable promise in the treatment of homologous recombination (HR)-defective tumors, such as BRCA1- and BRCA2-deficient breast and ovarian cancers. We previously reported that mantle cell lymphoma cells with deficiency i...

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Autori principali: Kubota, Eiji, Williamson, Christopher T, Ye, Ruiqiong, Elegbede, Anifat, Peterson, Lars, Lees-Miller, Susan P, Bebb, D Gwyn
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111704/
https://ncbi.nlm.nih.gov/pubmed/24841718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.29212
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