Retinoblastoma cells activate the AKT pathway and are vulnerable to the PI3K/mTOR inhibitor NVP-BEZ235

Retinoblastoma is a pediatric cancer of the retina most often caused by inactivation of the retinoblastoma (RB1) tumor suppressor gene. We previously showed that Rb1 loss cooperates with either co-activating the phosphatidylinositol 3-kinase (PI3K)/AKT pathway, or co-deleting Pten, to initiate retin...

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Udgivet i:Oncotarget
Main Authors: Xie, Chencheng, Freeman, Matthew J., Lu, Huarui, Wang, Xiaohong, Forster, Colleen L., Sarver, Aaron L., Hallstrom, Timothy C.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Priority Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503517/
https://ncbi.nlm.nih.gov/pubmed/28445155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16970
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