The U6 snRNA m(6)A methyltransferase METTL16 regulates SAM synthetase intron retention

Maintenance of proper levels of the methyl donor S-adenosylmethionine (SAM) is critical for a wide variety of biological processes. We demonstrate that the N(6)-adenosine methyltransferase METTL16 regulates expression of human MAT2A, which encodes the SAM synthetase expressed in most cells. Upon SAM...

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Publicado en:Cell
Autores principales: Pendleton, Kathryn E., Chen, Beibei, Liu, Kuanqing, Hunter, Olga V., Xie, Yang, Tu, Benjamin P., Conrad, Nicholas K.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502809/
https://ncbi.nlm.nih.gov/pubmed/28525753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.05.003
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