Subunit-specific role for the amino-terminal domain of AMPA receptors in synaptic targeting

The amino-terminal domain (ATD) of AMPA receptors (AMPARs) accounts for approximately 50% of the protein, yet its functional role, if any, remains a mystery. We have discovered that the translocation of surface GluA1, but not GluA2, AMPAR subunits to the synapse requires the ATD. GluA1A2 heteromers...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Díaz-Alonso, Javier, Sun, Yujiao J., Granger, Adam J., Levy, Jonathan M., Blankenship, Sabine M., Nicoll, Roger A.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2017
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502653/
https://ncbi.nlm.nih.gov/pubmed/28630296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707472114
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires