Biosynthesis of isonitrile lipopeptides by conserved nonribosomal peptide synthetase gene clusters in Actinobacteria

A putative lipopeptide biosynthetic gene cluster is conserved in many species of Actinobacteria, including Mycobacterium tuberculosis and M. marinum, but the specific function of the encoding proteins has been elusive. Using both in vivo heterologous reconstitution and in vitro biochemical analyses,...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Harris, Nicholas C., Sato, Michio, Herman, Nicolaus A., Twigg, Frederick, Cai, Wenlong, Liu, Joyce, Zhu, Xuejun, Downey, Jordan, Khalaf, Ryan, Martin, Joelle, Koshino, Hiroyuki, Zhang, Wenjun
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502637/
https://ncbi.nlm.nih.gov/pubmed/28634299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705016114
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