Biosynthesis of isonitrile lipopeptides by conserved nonribosomal peptide synthetase gene clusters in Actinobacteria

A putative lipopeptide biosynthetic gene cluster is conserved in many species of Actinobacteria, including Mycobacterium tuberculosis and M. marinum, but the specific function of the encoding proteins has been elusive. Using both in vivo heterologous reconstitution and in vitro biochemical analyses,...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Harris, Nicholas C., Sato, Michio, Herman, Nicolaus A., Twigg, Frederick, Cai, Wenlong, Liu, Joyce, Zhu, Xuejun, Downey, Jordan, Khalaf, Ryan, Martin, Joelle, Koshino, Hiroyuki, Zhang, Wenjun
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2017
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502637/
https://ncbi.nlm.nih.gov/pubmed/28634299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705016114
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