G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis

G9a is an epigenetic regulator that methylates H3K9, generally causing repression of gene expression, and participates in diverse cellular functions. G9a is genetically deregulated in a variety of tumor types and can silence tumor suppressor genes and, therefore, is important for carcinogenesis. Alt...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Casciello, Francesco, Al-Ejeh, Fares, Kelly, Greg, Brennan, Donal J., Ngiow, Shin Foong, Young, Arabella, Stoll, Thomas, Windloch, Karolina, Hill, Michelle M., Smyth, Mark J., Gannon, Frank, Lee, Jason S.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502591/
https://ncbi.nlm.nih.gov/pubmed/28630300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618706114
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