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Enhancing dengue virus maturation using a stable furin over-expressing cell line
Flaviviruses are positive-stranded RNA viruses that incorporate envelope (E) and premembrane (prM) proteins into the virion. Furin-mediated cleavage of prM defines a required maturation step in the flavivirus lifecycle. Inefficient prM cleavage results in structurally heterogeneous virions with uniq...
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| Publicado en: | Virology |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5502530/ https://ncbi.nlm.nih.gov/pubmed/27420797 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2016.06.022 |
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