Enhancing dengue virus maturation using a stable furin over-expressing cell line

Flaviviruses are positive-stranded RNA viruses that incorporate envelope (E) and premembrane (prM) proteins into the virion. Furin-mediated cleavage of prM defines a required maturation step in the flavivirus lifecycle. Inefficient prM cleavage results in structurally heterogeneous virions with uniq...

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Bibliographic Details
Published in:Virology
Main Authors: Mukherjee, Swati, Sirohi, Devika, Dowd, Kimberly A., Chen, Zhenguo, Diamond, Michael S., Kuhn, Richard J., Pierson, Theodore C.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502530/
https://ncbi.nlm.nih.gov/pubmed/27420797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2016.06.022
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