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A Fast Association Test for Identifying Pathogenic Variants Involved in Rare Diseases

We present a rapid and powerful inference procedure for identifying loci associated with rare hereditary disorders using Bayesian model comparison. Under a baseline model, disease risk is fixed across all individuals in a study. Under an association model, disease risk depends on a latent bipartitio...

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Bibliografiske detaljer
Udgivet i:Am J Hum Genet
Main Authors: Greene, Daniel, Richardson, Sylvia, Turro, Ernest
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501869/
https://ncbi.nlm.nih.gov/pubmed/28669401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2017.05.015
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