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Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA
Off-target or random integration of exogenous DNA hampers precise genomic engineering and presents a safety risk in clinical gene therapy strategies. Genetic definition of random integration has been lacking for decades. Here, we show that the A-family DNA polymerase θ (Pol θ) promotes random integr...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5501794/ https://ncbi.nlm.nih.gov/pubmed/28687761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00124-3 |
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