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Ultra-sensitive Sequencing Identifies High Prevalence of Clonal Hematopoiesis-Associated Mutations throughout Adult Life

Clonal hematopoiesis results from somatic mutations in hematopoietic stem cells, which give an advantage to mutant cells, driving their clonal expansion and potentially leading to leukemia. The acquisition of clonal hematopoiesis-driver mutations (CHDMs) occurs with normal aging and these mutations...

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Bibliografski detalji
Izdano u:Am J Hum Genet
Glavni autori: Acuna-Hidalgo, Rocio, Sengul, Hilal, Steehouwer, Marloes, van de Vorst, Maartje, Vermeulen, Sita H., Kiemeney, Lambertus A.L.M., Veltman, Joris A., Gilissen, Christian, Hoischen, Alexander
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501773/
https://ncbi.nlm.nih.gov/pubmed/28669404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2017.05.013
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